HOMOLOGATION OF ACIDS via CARBON RADICALS GENERATED FROM THE ACYL DERIVATIVES OF N-HYDROXY-2-THIOPYRIDONE. (THE TWO-CARBON PROBLEM).

Article abstract of DOI:10.1016/S0040-4039(00)92693-5

Reaction of suitable substituted olefins with carbon radicals generated from the acyl derivatives of N-hydroxy-2-thiopyridone results in the formation of precursors for the corresponding homo-acids.These compounds can then be transformed to the desired end-products in high yield under mild conditions.