Highly enantioselective routes to Darzens and acetate aldol products from achiral aldehydes and t-butyl bromoacetate

Article abstract of DOI:10.1016/0040-4039(91)80631-F

New methodology is described for the enantioselective coupling of t-butyl bromoacetate with aldehydes to give anti-α-bromo β-hydroxy esters (1), useful precursors of chiral glycidic esters (2), acetate aldols (3), β-amino acid esters (4) and α-amino acid