Highly enantioselective routes to Darzens and acetate aldol products from achiral aldehydes and t-butyl bromoacetate

DOI: 10.1016/0040-4039(91)80631-F

Source and publish data:

Tetrahedron Letters p. 2857 - 2860 (1991)

Update date:2022-07-29

Topics:

Authors:

Corey Corey

Choi Choi

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Article abstract of DOI:10.1016/0040-4039(91)80631-F

New methodology is described for the enantioselective coupling of t-butyl bromoacetate with aldehydes to give anti-α-bromo β-hydroxy esters (1), useful precursors of chiral glycidic esters (2), acetate aldols (3), β-amino acid esters (4) and α-amino acid

Full text of DOI:10.1016/0040-4039(91)80631-F

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Product name:t-butyl (2S,3S)-(+)-2-bromo-3-hydroxy-3-phenylpropionate

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