Synthesis of β-hydroxy-α-amino acids by aldol condensation using a chiral phase transfer catalyst

Article abstract of DOI:10.1016/S0040-4020(01)80971-6

Efficient, nearly racemic syntheses of β-hydroxy-α-amino acids by aldol condensations between t-butyl (diphenylmethylene)glycinate 2 and aldehydes under phase transfer catalytic conditions in the presence of the chiral catalyst N-benzylcinchoninium chloride are described.