Research on Chemical Intermediates p. 1819 - 1826 (2012)
Update date:2022-07-29
Topics:
Krishnakumar
Khan, Fazlur-Rahman Nawaz
Mandal, Badal Kumar
Mitta, Sukanya
Dhasamandha, Ramu
Govindan, Vindhya Nanu
The ethyl-2-chloroquinoline-3-carboxylates, 4, were achieved fromo-aminobenzophenones in two steps. i.e. initially, the ethyl-2-oxoquinoline- 3-carboxylates, 3, were obtained by base-catalyzed Friedlander condensations of o-aminobenzophenones, 1, and diethylmalonate, 2. The 2-chloroquinoline-3- carboxylates, 4, were then obtained by the reaction with POCl3 in good yields. The chemical structures were confirmed by FTIR, mass and 1H-NMR spectroscopic techniques. All the synthesized compounds were tested for their in vitro antibacterial activity against Bacillus subtilis and Vibrio cholera and found to possess moderate activity. Springer Science+Business Media B.V. 2012.
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