2′-aminoethoxy-2-amino-3-methylpyridine in triplex-forming oligonucleotides: High affinity, selectivity and resistance to enzymatic degradation

DOI: 10.1002/chem.201102287

Source and publish data:

Chemistry - A European Journal p. 14851 - 14856 (2011)

Update date:2022-07-29

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Authors:

Lou, Chenguang

Shelbourne, Montserrat

Fox, Keith R.

Brown, Tom

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Article abstract of DOI:10.1002/chem.201102287

The phosphoramidite monomer of the C-nucleoside 2′-aminoethoxy-2- amino-3-methylpyridine (AE-MAP) has been synthesized for the first time and incorporated into triplex-forming oligonucleotides (TFOs). Ultraviolet melting and DNase I footprinting studies s

Full text of DOI:10.1002/chem.201102287

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