Pd-Catalyzed Regio- and Stereo-selective Carboxylation of Cycloalkanes with CO

Article abstract of DOI:10.1246/cl.1991.1433

The reactions of cycloalkanes with CO via the C-H bond activation by Pd(OAc)2 catalyst have been found to proceed regio- and stereo-selectively to give corresponding carboxylic acids.The reactivity of C-H bonds of cycloalkanes decreases in the order: tert- > sec- > prim-carbon, and the stereochemistry of the substitutents on the main products is all equatorial.