3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs

DOI: 10.1021/jm00099a009

Source and publish data:

Journal of Medicinal Chemistry p. 3813 - 3821 (1992)

Update date:2022-07-30

Topics:

Authors:

Hartman Hartman

Halczenko

Duggan Duggan

Imagire Imagire

Smith Smith

Pitzenberger

Fitzpatrick

Alberts Alberts

Bostedor

Chao Chao

Germershausen

Gilfillan

Hunt Hunt

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Article abstract of DOI:10.1021/jm00099a009

Substitution of hydroxy and hydroxyalkyl functionality at C-7 of the hexahydronaphthalene nucleus of simvastatin has provided novel analogs. The synthetic strategy employed epoxidation or Lewis acid-catalyzed aldol reaction of the 8-keto silyl enol ether

Full text of DOI:10.1021/jm00099a009

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