Journal of Medicinal Chemistry p. 3813 - 3821 (1992)
Update date:2022-07-30
Topics:
Hartman
Halczenko
Duggan
Imagire
Smith
Pitzenberger
Fitzpatrick
Alberts
Bostedor
Chao
Germershausen
Gilfillan
Hunt
Substitution of hydroxy and hydroxyalkyl functionality at C-7 of the hexahydronaphthalene nucleus of simvastatin has provided novel analogs. The synthetic strategy employed epoxidation or Lewis acid-catalyzed aldol reaction of the 8-keto silyl enol ether
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