Synthesis of (+)-2,8-dihydroxyethyl-1,4,7,10-tetraoxaspiro[5.5]undecane from (R)-4-hydroxymethyl-2,2-dimethyl-1,3-dioxane

Article abstract of DOI:10.1016/S0957-4166(96)00517-4

Selective transformations of diethyl (R)-malate afforded (R)-4-hydroxymethyl 2,2-dimethyl-1,3-dioxane 7 in reasonable yield. Subsequent synthesis of (2S,6R,8S)-2,8-di hydroxyethyl-1,4,7,10-tetraoxaspiro[5.5]undecane 11 was achieved using precursor 7.