Efficient one-pot synthesis of substituted pyrido[2,3-d]pyrimidines from vinamidinium and chloropropeniminium salts

Article abstract of DOI:10.1080/00397911.2010.545163

A novel and efficient one-pot preparation of 6-substituted pyrido-[2,3-d]pyrimidines by cyclocondensation of 6-amino-1,3-dimethyluracil with symmetrical vinamidinium salts under basic conditions has been developed. Regioselectivity was observed with an unsymmetrical chloropropeniminium salt. Copyright Taylor & Francis Group, LLC.