Intramolecular cycloaddition reactions of dienyl nitroso compounds: Application to the synthesis of mitomycin K

DOI: 10.1021/ja00079a010

Source and publish data:

Journal of the American Chemical Society p. 12305 - 12314 (1993)

Update date:2022-07-29

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Authors:

Benbow, John W.

McClure, Kim F.

Danishefsky, Samuel J.

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Article abstract of DOI:10.1021/ja00079a010

The total synthesis of mitomycin K has been achieved. The key reaction produced pyrrolo[1,2-a]indole 25 from dienyl nitrobenzenemethanol 23 by a process involving two internal photochemical redox transformations and a [4 + 2] cycloaddition.

Full text of DOI:10.1021/ja00079a010

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