Intramolecular cycloaddition reactions of dienyl nitroso compounds: Application to the synthesis of mitomycin K

DOI: 10.1021/ja00079a010

Source and publish data:

Journal of the American Chemical Society p. 12305 - 12314 (1993)

Update date:2022-07-29

Topics:

Authors:

Benbow, John W.

McClure, Kim F.

Danishefsky, Samuel J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/ja00079a010

The total synthesis of mitomycin K has been achieved. The key reaction produced pyrrolo[1,2-a]indole 25 from dienyl nitrobenzenemethanol 23 by a process involving two internal photochemical redox transformations and a [4 + 2] cycloaddition.

Full text of DOI:10.1021/ja00079a010

Products guided by the article

Product name:2-hydroxy-3,5-dimethoxy-4-methyl-6-nitrobenzenemethanol

Cas No:136763-94-5

R&D Labs maybe for 136763-94-5

Shanghai He Yang International Trading Co., Ltd.

Contact:+86-21-52043598

Address:Room 816, Blag.5, No.58 Huachi Road
Shanghai agrotree chemical co.,ltd.

Contact:+86-21-50117563

Address:Room 8A,liangfeng building,No.8 dongfang RD.pudong,shanghai,China
Wuhan Yitongtai Science and Technology Co.,Ltd.

Contact:+86-27-88933550

Address:27th Fl. Bldg. 1, Shuian International Mansion, Heping Ave, Wuhan, Hubei, China
ZhangJiaGang YaRui Chemical Co.,Ltd.

Contact:0512-58360968

Address:China JiangSu Province Zhang Jia Gang City YangShe Oriental Plaza Building 10 B307
Shao Xing Empire Import&Export CO.,ltd

Contact:86-575-82127757

Address:11#, Weiwu Road, Shangyu Industrial Park, Hangzhou Bay, Hangzhou, Zhejiang Province, China

Relevant to this article

Rh₂(S-biTISP)₂-catalyzed asymmetric functionalization of indoles and pyrroles with vinylcarbenoids

Doi:10.1021/ol300632p
(2012)
An acid labile arginine derivative for peptide synthesis: N(G)-2,2,5,7,8-pentamethylchroman-6-sulphonyl-L-arginine

Doi:10.1016/S0040-4020(01)86564-9
(1991)
Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 2. Tadalafil analogs

Doi:10.1016/j.bmcl.2012.01.118
(2012)
Design and synthesis of 4-amino-2-phenylquinazolines as novel topoisomerase i inhibitors with molecular modeling

Doi:10.1016/j.bmc.2011.05.012
(2011)
DIASTEREOSPECIFIC SYNTHESIS OF 2,6-DIDEOXY- AND 2,4,6-TRIDEOXY-SUGARS VIA HETERO-DIELS-ALDER-REACTION

Doi:10.1016/S0040-4039(00)94780-4
(1985)
New insight into the central benzodiazepine receptor-ligand interactions: Design, synthesis, biological evaluation, and molecular modeling of 3-substituted 6-phenyl-4 H -imidazo[1,5- a][1,4]benzodiazepines and related compounds

Doi:10.1021/jm2001597
(2011)

Article Doi