Rational Design, Synthesis, and Pharmacological Characterization of Novel Ghrelin Receptor Inverse Agonists as Potential Treatment against Obesity-Related Metabolic Diseases

DOI: 10.1021/acs.jmedchem.8b00794

Source and publish data:

Journal of Medicinal Chemistry p. 11039 - 11060 (2018)

Update date:2022-08-15

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Authors:

Daina, Antoine

Giuliano, Claudio

Pietra, Claudio

Wang, Junbo

Chi, Yushi

Zou, Zack

Li, Fugang

Yan, Zhonghua

Zhou, Yifan

Guainazzi, Angelo

Garcia Rubio, Silvina

Zoete, Vincent

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Article abstract of DOI:10.1021/acs.jmedchem.8b00794

A new chemotype of ghrelin inverse agonists was discovered through chimeric design based on molecular scaffolds known as growth-hormone secretagogue receptor (GHSR) modulators but with divergent pharmacodynamic and pharmacokinetic properties. The structur

Full text of DOI:10.1021/acs.jmedchem.8b00794

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