Efficient synthesis of 3-substituted lactams using Meerwein Eschenmoser Claisen [3,3] sigmatropic rearrangements

DOI: 10.1016/S0040-4039(00)79904-7

Source and publish data:

Tetrahedron Letters p. 4199 - 4202 (1991)

Update date:2022-09-26

Topics:

Authors:

Coates Coates

Montgomery

Stevenson

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Article abstract of DOI:10.1016/S0040-4039(00)79904-7

3-Allyl substituted five, six and seven membered ring lactams are readily available in good yields and reasonable selectivity by a formal Meerwein Eschenmoser Claisen [3,3] rearrangement, using the readily available N,N-dialkylalkoxymethylene iminium salts and lithium alkoxides derived from allyl alcohols.

Full text of DOI:10.1016/S0040-4039(00)79904-7

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