Synthesis of unsymmetrically substituted benzils via the Friedel-Crafts reaction of arenes with α-chloro-α-(methylthio)acetophenones

DOI: 10.1248/cpb.39.1854

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1854 - 1856 (1991)

Update date:2022-08-05

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Authors:

Ishibashi

Matsuoka

Ikeda Ikeda

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Article abstract of DOI:10.1248/cpb.39.1854

Lewis acid-promoted reactions of arenes with α-chloro-α-(methylthio)acetophenones gave the Friedel-Crafts reaction products, which were then treated with 3 molar eq of cupric chloride in aqueous acetone to afford the unsymmetrically substituted benzils.

Full text of DOI:10.1248/cpb.39.1854

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Product name:2-Chloro-1-(3,4-dimethoxy-phenyl)-2-methylsulfanyl-ethanone

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