Tetrahedron Asymmetry p. 1049 - 1054 (1992)
Update date:2022-07-29
Topics:
Wirz, Beat
Walther, Willy
t-Butyl (R)-3-(hydroxymethyl)-1-piperidinecarboxylate was prepared with lipase P in up to 98 percent ee by means of enantioselective esterification of the racemic alcohol as well as by enantioselective hydrolysis of the corresponding butyryl ester and subsequent chemical hydrolysis of the retained (R)-ester.A work-up procedure feasible on the kg-scale is described.
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Doi:10.1016/S0040-4039(00)94780-4
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