Tetrahedron Asymmetry p. 1049 - 1054 (1992)
Update date:2022-07-29
Topics:
Wirz, Beat
Walther, Willy
t-Butyl (R)-3-(hydroxymethyl)-1-piperidinecarboxylate was prepared with lipase P in up to 98 percent ee by means of enantioselective esterification of the racemic alcohol as well as by enantioselective hydrolysis of the corresponding butyryl ester and subsequent chemical hydrolysis of the retained (R)-ester.A work-up procedure feasible on the kg-scale is described.
View MoreTianjin Boron PharmaTech Co.,Ltd.(expird)
Contact:86-022-59845187
Address:B9-401, Tianda Science Park,No.80,4th Avenue,TEDA,Tianjin, China
Contact:+86-22-26358246
Address:601-4-20, Fujiayuan, Tiantai Road, Hebei District, Tianjin, China
Contact:0086-21-80264647
Address:RM 202, NO 1602 West Zhongshan Rd, Shanghai, China
website:http://www.synchemie.com/
Contact:+86-574-87642758
Address:Room 901, Yinyi Bund Building， 132 Renmin Road
Shanghai Science Peptide Biological Technology Co.,ltd
website:http://www.scipeptide.com
Contact:+86-21-51099675
Address:No.8 Changyang Rd
Doi:10.1016/S0040-4039(00)94780-4
(1985)Doi:10.1021/jm2001597
(2011)Doi:10.1007/s00706-011-0468-8
(2011)Doi:10.1016/j.cclet.2016.09.006
(2017)Doi:10.1021/ol201717d
(2011)Doi:10.1002/jlcr.3557
(2017)
