An Efficient Synthesis of Hydroxyethylene Dipeptide Isosteres: The Core Unit of Potent HIV-1 Protease Inhibitors

DOI: 10.1021/jo00023a009

Source and publish data:

Journal of Organic Chemistry p. 6500 - 6503 (1991)

Update date:2022-07-30

Topics:

Authors:

Ghosh, Arun K.

McKee, Sean P.

Thompson, Wayne J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00023a009

An efficient and stereocontrolled synthesis of hydroxyethylene dipeptide isosteres 1 from commercially available, optically pure D-mannose is described.This synthesis represents a practical and enantioselective entry to a range of other dipeptide isostere

Full text of DOI:10.1021/jo00023a009

Products guided by the article

Product name:(R)-1-((S)-5-Methoxy-tetrahydro-furan-2-yl)-2-phenyl-ethanol

Cas No:137119-48-3

R&D Labs maybe for 137119-48-3

shanghai tuomiao chemicial co.,ltd.

website:https://www.tuomiaochem.com/

Contact:021 - 59853336

Address:shanghai
Shijiazhuang Sdyano Fine Chemical Co., Ltd

Contact:+86-311-89830448

Address:NO.48 Ta Nan Road,Yuhua District,Shijiazhuang,Hebei,China
Daicel Chiral Technologies (China)CO.,LTD

Contact:021-5046-0086*8

Address:Part C, FL 5, the 16th Building, No. 69, XiYa Road, WaiGaoQiao Free Trade Zone, Shanghai, 200131, P.R.China
Tradlon Chemical Co., Ltd.

Contact:+86-710-3516804

Address:Number 83,Panggong road,Xiangcheng District,Xiangyang ,Hubei
Yantai Derun Liquid Crystal Materials Co. Ltd.

website:http://www.ytderun.com

Contact:86-535-6300169

Address:ROOM 90, XIANGFU STREET, FUSHAN NEW-HIGH-TECH IDUSTRY ZONE, YANTAI

Relevant to this article

Palladium-catalyzed cycloaddition of alkynyl aryl ethers with internal alkynes via selective ortho C-H activation

Doi:10.1021/ja301588z
(2012)
Organophotoredox-Catalyzed Decarboxylative N-Alkylation of Sulfonamides

Doi:10.1002/cctc.202100803
(2021)
A convenient synthesis of 4-deoxypyrazofurin

Doi:10.1055/s-1991-26565
(1991)
A metal-free radical cascade reaction of phosphine oxides with 2-aryloxy phenylacetylenes to synthesize diphosphonyl xanthene derivatives

Doi:10.1039/d1ob01045j
(2021)
Fatty acids in heterocyclic synthesis part xii: Synthesis of surfactants from pyrazole, isoxazole, pyrimidine and triazine, incorporating the 1,3,4-thiadiazole moiety having dyeing and antimicrobial activities

Doi:10.1007/s11743-011-1301-4
(2012)
Tyrosine modified analogues of the α4β7 integrin inhibitor biotin-R₈ERY prepared via Click Chemistry: Synthesis and biological evaluation

Doi:10.1016/j.bmc.2012.02.035
(2012)

Article Doi