An Efficient Synthesis of Hydroxyethylene Dipeptide Isosteres: The Core Unit of Potent HIV-1 Protease Inhibitors

DOI: 10.1021/jo00023a009

Source and publish data:

Journal of Organic Chemistry p. 6500 - 6503 (1991)

Update date:2022-07-30

Topics:

Authors:

Ghosh, Arun K.

McKee, Sean P.

Thompson, Wayne J.

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Article abstract of DOI:10.1021/jo00023a009

An efficient and stereocontrolled synthesis of hydroxyethylene dipeptide isosteres 1 from commercially available, optically pure D-mannose is described.This synthesis represents a practical and enantioselective entry to a range of other dipeptide isostere

Full text of DOI:10.1021/jo00023a009

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