An Efficient Synthesis of Hydroxyethylene Dipeptide Isosteres: The Core Unit of Potent HIV-1 Protease Inhibitors

DOI: 10.1021/jo00023a009

Source and publish data:

Journal of Organic Chemistry p. 6500 - 6503 (1991)

Update date:2022-07-30

Topics:

Authors:

Ghosh, Arun K.

McKee, Sean P.

Thompson, Wayne J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00023a009

An efficient and stereocontrolled synthesis of hydroxyethylene dipeptide isosteres 1 from commercially available, optically pure D-mannose is described.This synthesis represents a practical and enantioselective entry to a range of other dipeptide isostere

Full text of DOI:10.1021/jo00023a009

Products guided by the article

Product name:(R)-1-((S)-5-Methoxy-tetrahydro-furan-2-yl)-2-phenyl-ethanol

Cas No:137119-48-3

R&D Labs maybe for 137119-48-3

Xinchang Yueding Chemical Co., Ltd.

Contact:86-571-56926323

Address:NO.90 BEIMENCHENGWAI CHENGGUAN TOWN XINCHANG
Hangzhou Yanshan Chemical Co.,Ltd.

Contact:86-571- 87698076

Address:Room 1001, #1 Building, Zhongtian MCC, No.2 Youzhinong, Wenyi West Road, Xihu District, Hangzhou, China
shanghai jiuling chemical co.,ltd.

Contact:+86-21-50387295

Address:Zaozhuang Road, Pudong, Shanghai City. China
MINS GROUP CO.,LIMITED

Contact:18669908765

Address:Zibo City, Shandong Province, P.R.China
Hangzhou Neway Chemicals Co., Ltd.

Contact:+86-571-85095566

Address:Room 803, Qinglian Bldg, No 139 Qingchun Road, Hangzhou, Zhejiang China

Relevant to this article

Palladium-catalyzed cycloaddition of alkynyl aryl ethers with internal alkynes via selective ortho C-H activation

Doi:10.1021/ja301588z
(2012)
Organophotoredox-Catalyzed Decarboxylative N-Alkylation of Sulfonamides

Doi:10.1002/cctc.202100803
(2021)
A convenient synthesis of 4-deoxypyrazofurin

Doi:10.1055/s-1991-26565
(1991)
A metal-free radical cascade reaction of phosphine oxides with 2-aryloxy phenylacetylenes to synthesize diphosphonyl xanthene derivatives

Doi:10.1039/d1ob01045j
(2021)
Fatty acids in heterocyclic synthesis part xii: Synthesis of surfactants from pyrazole, isoxazole, pyrimidine and triazine, incorporating the 1,3,4-thiadiazole moiety having dyeing and antimicrobial activities

Doi:10.1007/s11743-011-1301-4
(2012)
Tyrosine modified analogues of the α4β7 integrin inhibitor biotin-R₈ERY prepared via Click Chemistry: Synthesis and biological evaluation

Doi:10.1016/j.bmc.2012.02.035
(2012)

Article Doi