A new enantioseletive synthesis of (4S, 5S)-5-(N-Boc)-amino-6-cyclohexyl-4-hydroxy-hexanoic acid lactone, a hydroxyethylene dipeptide isostere precursor

Article abstract of DOI:10.1016/0040-4039(91)80024-Z

A new enantioselective synthesis of a valuable hydroxyethylene dipeptide isostere precursor, (4S,5S)-5-(N-Boc)-amino-6-cyclohexyl-4-hydroxy-hexanoic acid lactone, has been developed by using coupling reaction of chiral triflates as a key step.