A new enantioseletive synthesis of (4S, 5S)-5-(N-Boc)-amino-6-cyclohexyl-4-hydroxy-hexanoic acid lactone, a hydroxyethylene dipeptide isostere precursor

DOI: 10.1016/0040-4039(91)80024-Z

Source and publish data:

Tetrahedron Letters p. 4503 - 4504 (1991)

Update date:2022-09-26

Topics:

Authors:

Kotsuki Kotsuki

Miyazaki

Ochi Ochi

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Article abstract of DOI:10.1016/0040-4039(91)80024-Z

A new enantioselective synthesis of a valuable hydroxyethylene dipeptide isostere precursor, (4S,5S)-5-(N-Boc)-amino-6-cyclohexyl-4-hydroxy-hexanoic acid lactone, has been developed by using coupling reaction of chiral triflates as a key step.

Full text of DOI:10.1016/0040-4039(91)80024-Z

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Product name:((4S,5R)-5-Cyclohexylmethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-methanol

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