Design and Synthesis of Potent, Selective, and Orally Active Fluorine-Containing Renin Inhibitors

Article abstract of DOI:10.1021/jm00079a001

A series of primate renin inhibitors containing difluorocarbinol and difluoroketone groups at the P₁ - P_1' position have been synthesized and studied both in vitro and in vivo.In vitro, the compounds were evaluated as inhibitors of m