Design and Synthesis of Potent, Selective, and Orally Active Fluorine-Containing Renin Inhibitors

DOI: 10.1021/jm00079a001

Source and publish data:

Journal of Medicinal Chemistry p. 2 - 14 (1992)

Update date:2022-08-05

Topics:

Authors:

Doherty, Annette M.

Sircar, Ila

Kornberg, Brian E.

Quin, John

Winters, Thomas R.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00079a001

A series of primate renin inhibitors containing difluorocarbinol and difluoroketone groups at the P₁ - P_1' position have been synthesized and studied both in vitro and in vivo.In vitro, the compounds were evaluated as inhibitors of m

Full text of DOI:10.1021/jm00079a001

Products guided by the article

Product name:N-<2-<<1(S)-(cyclohexylmethyl)-3,3-difluoro-4-<<2-(4-morpholinyl)ethyl>amino>-2,4-dioxobutyl>amino>-2-oxo-1-propoxyethyl>-α-<(4-morpholinylsulfonyl)amino>benzenepropanamide

Cas No:137302-56-8

R&D Labs maybe for 137302-56-8

Henan Harvest Chem Co., Ltd

Contact:+86-371-86058576

Address:NO.32, Jingsan Road, Zhengzhou, China
Taizhou Huading Chemical Co.,Ltd(expird)

Contact:+86-576-88583898

Address:Economic&Technology development zone,Taizhou City,Zhejiang Province,China
JiangXi Hong Run Chemical Co., Ltd

Contact:+86-0791-88521351

Address:XingHuo industrial zone in YongXiu county
Shandong Zhongcheng Barium Salt Co., Ltd

Contact:+86-15725732638

Address:No.29 baoxi road, hi-tech zone, zibo, shandong
SHANXI JINJIN CHEMICAL INDUSTRIAL CO.,LTD

website:http://www.jinjingroup.com

Contact:86-574-13989382828

Address:Economic And Technological Development Zone,Hejin?City,Shanxi Province?,China

Relevant to this article

Unexpected course of the reaction of 2-unsubstituted 1H-Imidazole 3-oxides with ethyl acrylate

Doi:10.1002/hlca.201100519
(2012)
REACTIONS OF POLYFLUOROALKYLSULFENYL CHLORIDES WITH PHENOLS

Doi:10.1007/BF00961248
(1991)
Preparation of methylhydrazine and methyldiazene complexes of molybdenum and tungsten

Doi:10.1016/j.poly.2012.03.004
(2012)
Synthesis of potential antitubercular and antimicrobial s-triazine-based scaffolds via Suzuki cross-coupling reaction

Doi:10.1007/s00044-012-0041-y
(2013)
Dehydrative C-H alkylation and alkenylation of phenols with alcohols: Expedient synthesis for substituted phenols and benzofurans

Doi:10.1021/ja302710v
(2012)
Formation of tertiary amides and dihydrogen by dehydrogenative coupling of primary alcohols with secondary amines catalyzed by ruthenium bipyridine-based pincer complexes

Doi:10.1002/adsc.201300620
(2013)

Article Doi