Design and Synthesis of Potent, Selective, and Orally Active Fluorine-Containing Renin Inhibitors

DOI: 10.1021/jm00079a001

Source and publish data:

Journal of Medicinal Chemistry p. 2 - 14 (1992)

Update date:2022-08-05

Topics:

Authors:

Doherty, Annette M.

Sircar, Ila

Kornberg, Brian E.

Quin, John

Winters, Thomas R.

et al. et al.

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Article abstract of DOI:10.1021/jm00079a001

A series of primate renin inhibitors containing difluorocarbinol and difluoroketone groups at the P₁ - P_1' position have been synthesized and studied both in vitro and in vivo.In vitro, the compounds were evaluated as inhibitors of m

Full text of DOI:10.1021/jm00079a001

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