Stereoselective Radical-Mediated Cyclization of Norephedrine Derived α-Iodoamides: Experiments and TS-Modelling

DOI: 10.1016/S0957-4166(00)80462-0

Source and publish data:

Tetrahedron Asymmetry p. 793 - 796 (1991)

Update date:2022-08-04

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Authors:

Gennari, Cesare

Poli, Giovanni

Scolastico, Carlo

Vassallo, Marco

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Article abstract of DOI:10.1016/S0957-4166(00)80462-0

Radical-mediated cyclization of norephedrine derived α-iodoamides 1 was found to be highly stereoselective (<*>97:3) favouring diastereoisomer 2.Transition state modelling with a force field developed ad hoc, nicely predicts the stereochemical results.

Full text of DOI:10.1016/S0957-4166(00)80462-0

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