Regioselectivity in Intramolecular Nucleophilic Aromatic Substitution. Synthesis of the Potent Anti HIV-1 8-Halo TIBO Analogues

DOI: 10.1021/jo00027a019

Source and publish data:

Journal of Organic Chemistry p. 97 - 100 (1992)

Update date:2022-07-29

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Authors:

Parker, Kathlyn A.

Coburn, Craig A.

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Article abstract of DOI:10.1021/jo00027a019

Regioselective intramolecular nucleophilic substitution of 2,6-dihalo-3-nitrobenzyl diamines 2b and 2c gave benzodiazepines 3.These intermediates are useful in the preparation of the 8-halo TIBO derivatives 1, inhibitors of HIV-I replication in cell cultu

Full text of DOI:10.1021/jo00027a019

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