Total synthesis of (+)-leukotriene B4 methyl ester and its 5-epimer from (R)-glycidol

Article abstract of DOI:10.1016/S0040-4020(01)89730-1

The Pd-Cu coupling reaction of a chiral hydroxy-(E,E)-iododiene with a racemic acetylenic alcohol followed by reduction of the dienyne leads to the desired (Z,E,E) geometry and allows synthesis of LTB₄ and its 5-epimer after separation of diast