Preparation of modified peptides: Direct conversion of α-amino acids into β-amino aldehydes

Article abstract of DOI:10.1039/c2ob25433f

A direct method for the transformation of α-amino acids into β-amino aldehydes was developed, and applied to the modification of the C-terminal residue of peptides. The method takes place in good yields and under mild conditions. The application of this methodology to the preparation of small peptides with γ-amino alcohol units, which are precursors of analogues of peptaibol antibiotics, is also described.