CHEMOENZYMATIC SYNTHESIS OF A C5-CHIRAL BUILDING BLOCK: A SUBSTRATE MODIFICATION APPROACH.

DOI: 10.1016/S0040-4039(00)96663-2

Source and publish data:

Tetrahedron Letters p. 4935 - 4938 (1987)

Update date:2022-07-30

Topics:

Authors:

Roy, Rene

Rey, Allan, W.

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Article abstract of DOI:10.1016/S0040-4039(00)96663-2

The enantioselectivity of α-chymotrypsin hydrolysis of prochiral dimethyl-3-hydroxyglutarates was contrilled by the proper choice of the hydroxyl protecting groups.This strategy allows the synthesis of a versatile C₅-chiral building block.

Full text of DOI:10.1016/S0040-4039(00)96663-2

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