4-Substituted 2-alkoxytetrahydrofurans as potent and long-lasting PAF antagonists

DOI: 10.1021/jm00082a007

Source and publish data:

Journal of Medicinal Chemistry p. 676 - 683 (1992)

Update date:2022-07-30

Topics:

Authors:

Carceller

Merlos Merlos

Giral Giral

Bartroli

Garcia-Rafanell

Forn Forn

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Article abstract of DOI:10.1021/jm00082a007

A series of 4-substituted 2-alkoxytetrahydrofuran derivatives featuring an acetal group were prepared and evaluated for PAF antagonist activity in the PAF-induced in vitro platelet-aggregation and in vivo hypotension tests. Compound 2-[[N-acetyl-N-[[[2-(o

Full text of DOI:10.1021/jm00082a007

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