Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors

DOI: 10.1021/jm00081a002

Source and publish data:

Journal of Medicinal Chemistry p. 423 - 430 (1992)

Update date:2022-08-02

Topics:

Authors:

Mach Mach

Jackson Jackson

Luedtke Luedtke

Ivins Ivins

Molinoff

Ehrenkaufer

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Article abstract of DOI:10.1021/jm00081a002

Two series of N-substituted spiperone analogues were prepared and evaluated in vitro to measure their affinities for dopamine D₂ and serotonin 5-HT₂ receptors. Substitution of the amide nitrogen with an alkyl group of five carbon uni

Full text of DOI:10.1021/jm00081a002

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