Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors

Article abstract of DOI:10.1021/jm00081a002

Two series of N-substituted spiperone analogues were prepared and evaluated in vitro to measure their affinities for dopamine D₂ and serotonin 5-HT₂ receptors. Substitution of the amide nitrogen with an alkyl group of five carbon uni