Effect of N-alkylation on the affinities of analogues of spiperone for dopamine D2 and serotonin 5-HT2 receptors

DOI: 10.1021/jm00081a002

Source and publish data:

Journal of Medicinal Chemistry p. 423 - 430 (1992)

Update date:2022-08-02

Topics:

Authors:

Mach Mach

Jackson Jackson

Luedtke Luedtke

Ivins Ivins

Molinoff

Ehrenkaufer

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00081a002

Two series of N-substituted spiperone analogues were prepared and evaluated in vitro to measure their affinities for dopamine D₂ and serotonin 5-HT₂ receptors. Substitution of the amide nitrogen with an alkyl group of five carbon uni

Full text of DOI:10.1021/jm00081a002

Products guided by the article

Product name:1,3,8-Triazaspiro[4.5]decan-4-one, 8-[4-(4-fluorophenyl)-4-oxobutyl]-3-[(2-methoxyphenyl)methyl]-1-phenyl-

Cas No:138091-86-8

R&D Labs maybe for 138091-86-8

Shanghai ZaiQi Bio-Tech Co., Ltd.,

Contact:+86-21-5482 4098

Address:Bldg. No.7, No.201 MinYi Rd，Songjiang CaoHeJing High-Tech Park Shanghai 201516 P,R,China
Shanghai Forever Biotech Co., Ltd.

Contact:+86-21-69734790

Address:Room 5017/5019、5022、5024 of Technology Innovation Centre, No.1155, Gongyuan East Rd, QingPu District, Shanghai China.
Tianjin Jingye Fine Chemicals Co., Ltd.

Contact:+86-15722078107; +86-22-26911407

Address:Bohua Fine Chemicals Base of Petrochemical Industry Park, Nanhuan Road, Dagang District, Tianjin, 300271, P. R. China
shijiazhuang alkay chemicals co..ltd(expird)

Contact:86-311-67692035

Address:2601,juntang building,qiaodong district,shijiazhuang
AstaTech ( Chengdu) BioPharmaceutical Corp.

website:http://www.astabiochem.cn/

Contact:+86-15198215156-15198215156

Address:SICHUAN CHENGDU

Relevant to this article

Photoinduced molecular transformations. 158. A total synthesis of (±)-methyl piperitol: An unsymmetrically substituted 2,6-diaryl-3,7-dioxabicyclo[3.3.0.]octane lignan

Doi:10.1021/jo00124a045
(1995)
Organocatalytic enamine-activation of cyclopropanes for highly stereoselective formation of cyclobutanes

Doi:10.1021/ja512573q
(2015)
Asymmetric synthesis of protected 1,2-amino alcohols using tert-butanesulfinyl aldimines and ketimines

Doi:10.1021/jo0156868
(2001)
Total synthesis of (-)-eburnamonine and (+)-epi-eburnamonine from a chiral non-racemic 4,4-disubstituted γ-lactone

Doi:10.1016/S0040-4039(99)02131-0
(2000)
Synthesis of acridine-based DNA bis-intercalating agents

Doi:10.3390/60300230
(2001)
Thiosugar nucleotide analogues: Synthesis of uridine 5′-(2,3,6-tri-O-acetyl-4-S-acetyl-4-thio-α-D-galactopyranosyl diphosphate)

Doi:10.1016/S0008-6215(01)00228-2
(2001)

Article Doi