Total synthesis of tetronolide, the aglycon of tetrocarcins

Article abstract of DOI:10.1016/S0040-4039(00)93498-1

The first total synthesis of tetronolide (1) has been achieved via coupling of spirotetronate 3 with octahydronaphthalene aldehyde 17 and subsequent macrocyclization of ω-sulfone-α-aldehyde 2, leading to confirmation of the absolute configuration of 1.