Stereoselective Synthesis of 2,3-Dihydroxy-4-dimethylamino-5-methoxypentanoic Acid, A Fragment of Calyculins - Determination of the Absolute Configuration of Calyculins

DOI: 10.1016/S0040-4039(00)79444-5

Source and publish data:

Tetrahedron Letters p. 5983 - 5986 (1991)

Update date:2022-09-26

Topics:

Authors:

Hamada, Yasumasa

Tanada, Yoshihisa

Yokokawa, Fumiaki

Shiori, Takayuki

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Article abstract of DOI:10.1016/S0040-4039(00)79444-5

2,3-Dihydroxy-4-dimethylamino-5-methoxypentanoic acid (2) with (2R,3R,4R)-configuration has been stereoselectively prepared from (S)-pyroglutaminol (3) and revealed to be the enantiomer of the compound derived from calyculins (1), which provides the conclusicve evidence on the absolutr configuration of calyculins.

Full text of DOI:10.1016/S0040-4039(00)79444-5

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Product name:2-Pyrrolidinone, 5-[[(4-methoxyphenyl)methoxy]methyl]-1-[(4-methoxyphenyl)methyl]-, (S)-

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