
Chemical and Pharmaceutical Bulletin p. 2241 - 2246 (1991)
Update date:2022-08-04
Topics:
Konosu
Miyaoka
Tajima
Oida
Stereocontrolled synthesis of an optically active triazolylmethyloxirane 2, an important intermediate for the preparation of antifungal oxazolidine compounds 1, was achieved by two methods using L-lactic acid as a starting material. The key intermediate ketone 6 used in the procedures also served for the synthesis of the enantiomer of 2 and the corresponding diastereomeric epoxide.
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