Journal of Medicinal Chemistry p. 1828 - 1839 (1992)
Update date:2022-08-03
Topics: In vitro Antimicrobial activity Minimum inhibitory concentration (MIC) in vivo Chemical Structure Carbapenems
Corraz, Alfred J.
Dax, Scott L.
Dunlap, Norma K.
Georgopapadakou, Nafsika H.
Keith, Dennis D.
et al.
Two series of dual-action antibacterial agents were synthesized in which penems and carbapenems were linked at the 2'-position to quinolones through either an ester or a carbamate moiety.Potent, broad-spectrum antibacterial activity was observed for both
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