Journal of the American Chemical Society p. 11146 - 11152 (2012)
Update date:2022-08-05
Topics: Reaction 15N Hyperpolarization
Reineri, Francesca
Viale, Alessandra
Ellena, Silvano
Alberti, Diego
Boi, Tommaso
Giovenzana, Giovanni Battista
Gobetto, Roberto
Premkumar, Samuel S. D.
Aime, Silvio
15N-Propargylcholine has been synthesized and hydrogenated with para-H2. Through the application of a field cycling procedure, parahydrogen spin order is transferred to the 15N resonance. Among the different isomers formed upon hydrogenation of 15N- propargylcholine, only the nontransposed derivative contributes to the observed N-15 enhanced emission signal. The parahydrogen-induced polarization factor is about 3000. The precise identification of the isomer responsible for the observed 15N enhancement has been attained through a retro-INEPT (15N-1H) experiment. T1 of the hyperpolarized 15N resonance has been estimated to be ca. 150 s, i.e., similar to that reported for the parent propargylcholine (144 s). Experimental results are accompanied by theoretical calculations that stress the role of scalar coupling constants (JHN and JHH) and of the field dependence in the formation of the observed 15N polarized signal. Insights into the good cellular uptake of the compound have been gained.
View Morezhuzhou zhongle chemical co. ltd.
Contact:+86-0731 28228409
Address:Zhuzhou, Hunan, China
Chemieliva Pharmaceutical Co., Ltd.
website:http://www.chemieliva.com
Contact:+86-23-67770219
Address:99 Longhua Road, Yubei District, 401147, Chongqing, China Email: sales@chemieliva.com Tel:0086-23-67770219 Fax: 0086-23-67770220 Attn: Andy Huang
jintan yufan Medicine Raw materials Co.,Ltd.(expird)
Contact:86-519-82808282
Address:6th,Jincheng Huangzhuang
AllyChem Co., Ltd., Dalian, China(BBChem)
Contact:+86-411-62313318/62313328
Address:No.5 of Jinbin Road, Jinzhou New District, Dalian City, Liaoning Province, P.R.China
Contact:
Address:
Doi:10.1080/00397911.2011.576323
(2012)Doi:10.1002/ejic.201201112
(2013)Doi:10.1016/0957-4166(96)00026-2
(1996)Doi:10.1021/jm9805541
(1999)Doi:10.1016/0040-4039(91)80203-I
(1991)Doi:10.1016/S0008-6215(98)00044-5
(1998)