Organic Letters p. 3700 - 3703 (2012)
Update date:2022-08-04
Topics:
Wang, Min
Wang, Yanjie
Qi, Xueyong
Xia, Guohua
Tong, Kun
Tu, Jinchang
Pittman, Charles U.
Zhou, Aihua
From one starting material, two tandem reaction protocols to synthesize seven- and eight-membered ring sultams were developed. One protocol employs intermolecular epoxide ring-opening by NaN3, followed by an intramolecular 7-endo-trig oxa-Michael addition reaction. The second protocol applies to intermolecular aza-Michael addition of a primary amine, followed by 8-endo-tet intramolecular epoxide ring-opening of the resultant amine intermediate. Both protocols afforded the respective sultams in good yields under mild reaction conditions.
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Doi:10.1016/j.bmc.2012.05.046
(2012)Doi:10.1016/0008-6215(91)89057-M
(1991)Doi:10.1016/S0040-4039(00)01404-0
(2000)Doi:10.1016/S0040-4020(01)92438-X
(1981)Doi:10.1021/jo00032a024
(1992)Doi:10.1016/j.bmcl.2013.10.055
(2013)