The directed cleavage of substituted 1-phenylethylamines: A novel route to enantiomerically pure β-amino acid esters and β-lactams

DOI: 10.1055/s-1991-26583

Source and publish data:

Synthesis p. 829 - 831 (1991)

Update date:2022-07-29

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Authors:

Bringmann

Geuder Geuder

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Article abstract of DOI:10.1055/s-1991-26583

An efficient novel access to enantiomerically pure β-amino acid esters and β-lactams (e.g., methyl (3S,4S)-1-(tert-butyldimethylsilyl-4-methyl-2-oxoazetidine-3-carboxylat e) from optically active 1-arylethylamines is described. Regiospecific cleavage is performed by Birch reduction and subsequent ozonolysis.

Full text of DOI:10.1055/s-1991-26583

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