Lipase-catalyzed Enantioselective Hydrolysis of N-Acyloxymethyl Groups in Organic Solvent: Syntheses of Chiral 5,5-Disubstituted 1-Methylbarbiturates

DOI: 10.1016/S0040-4039(00)93597-4

Source and publish data:

Tetrahedron Letters p. 6763 - 6766 (1991)

Update date:2022-08-02

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Authors:

Murata, Masakazu

Achiwa, Kazuo

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Article abstract of DOI:10.1016/S0040-4039(00)93597-4

Chiral 5,5-disubstituted N-acyloxymethylbarbiturates have been obtained in 40-99percent optical yields by lipase-catalyzed hydrolyses of 5,5-disubstituted bisacyloxymethylbarbiturates in H2O-saturated diisopropyl ether.These chiral barbiturates were readi

Full text of DOI:10.1016/S0040-4039(00)93597-4

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