Synthesis of δ-(L-α-aminoadipoyl)-L-cysteinyl-D-(O-methyl)-D- allothreonine a substrate for isopenicillin-N synthase and its O-Methyl-D- threonine epimer

Article abstract of DOI:10.1016/S0040-4020(98)00280-4

The paper describes the synthesis of two epimeric tripeptides δ-(L-α- aminoadipoyl)-L-cysteinyl-D-(O-methyl)-D-threonine (13) and δ-(L-α- aminoadipoyl)-L-cysteinyl-D-(O-methyl)-D-allothreonine (14), modified substrates for the isopenicillin-N synthase enz