α-Substituted β-oxa isosteres of fosmidomycin: Synthesis and biological evaluation

DOI: 10.1021/jm300652f

Source and publish data:

Journal of Medicinal Chemistry p. 6566 - 6575 (2012)

Update date:2022-08-05

Topics:

Authors:

Brücher, Karin

Illarionov, Boris

Held, Jana

Tschan, Serena

Kunfermann, Andrea

Pein, Miriam K.

Bacher, Adelbert

Gr?wert, Tobias

Maes, Louis

Mordmüller, Benjamin

Fischer, Markus

Kurz, Thomas

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Article abstract of DOI:10.1021/jm300652f

Specific inhibition of enzymes of the non-mevalonate pathway is a promising strategy for the development of novel antiplasmodial drugs. α-Aryl-substituted β-oxa isosteres of fosmidomycin with a reverse orientation of the hydroxamic acid group were synthes

Full text of DOI:10.1021/jm300652f

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