A convenient synthetic methodology for the elaboration of the pyrido[2,3-b]- or [3,4-b]-pyrazine and [1,4]diazepine skeletons

Article abstract of DOI:10.1055/s-1991-26623

The condensation of the anion of 3-(formylamino)-2-chloropyridines, 3-(acetylamino)-2-chloro-, -4-chloro- or -2,4-dichloropyridines with various chloro-N,N-dimethylalkylamines gives rise efficiently to 1,2,3,4-tetrahydropyrido[2,3-b]- or [3,4-b]pyrazines and to 2,3,4,5-tetrahydro-1H-pyrido[2,3-b]- or [3,4-b][1,4]diazepines.