Rhodium(III)-Catalyzed Cross Coupling of Sulfoxonium Ylides and 1,3-Diynes to Produce Naphthol-Indole Derivatives: An Arene ortho C?H Activation/Annulation Cascade

Article abstract of DOI:10.1002/cctc.202001315

Synthesis of naphthol-indoles starting from easily available 1,3-diynes and sulfoxonium ylides via Rh^III-catalyzed C?H activation/hydroamination cascade process in a one pot manner has been developed. The reaction proceeds through a Rh^III-catalyzed arene ortho C?H activation and silver-catalyzed hydroamination cascade to afford a variety of C2 position functionalized indoles in good yields with broad substrate scope and good functional group tolerance.