Synthesis p. 989 - 993 (1991)
Update date:2022-08-02
Topics:
O'Donnell
Cook
Rusterholz
Higher imine esters 1a-h and 7a-b of amino acids and dipeptides are prepared in 68-91% yield by saponification of the benzophenone Schiff base methyl esters 3a-d and 6 using phase-transfer techniques followed by O-alkylation with an alkyl halide. The procedure occurs with retention of configuration at the α-carbon except with phenylglycine derivatives.
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Doi:10.1021/jo00052a051
(1992)Doi:10.1021/jf301621e
(2012)Doi:10.1016/0040-4039(91)80547-J
(1991)Doi:10.1021/jo300865d
(2012)Doi:10.1016/j.bioorg.2015.02.006
(2015)Doi:10.1002/anie.201709523
(2017)