A trans olefin replacement of the disulfide bridge found in cyclic peptides: Synthesis of 6,6-pentamethylene-2-amino-Δ4,5-suberic acid

Article abstract of DOI:10.1016/0040-4039(91)80476-M

Substitution of the sulfur atoms in the disulfide bridge of cyclic peptides with a trans olefin incorporates the features of a dicarba replacement while introducing a greater torsional restriction. The synthesis of the differentially protected racemic 6,6