Asymmetric dihydroxylation onto the α,β-unsaturated carboxylic ester derivatives of camptothecin

DOI: 10.3987/COM-97-7892

Source and publish data:

Heterocycles p. 1663 - 1669 (1997)

Update date:2022-08-03

Topics:

Authors:

Tagami, Keiko

Takagi, Shuzo

Sano, Shigeki

Shiro, Motoo

Nagao, Yoshimitsu

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Article abstract of DOI:10.3987/COM-97-7892

Dihydroxyalkanoic ester derivatives (4a,b) and (5a,b) of 20S-camptothecin (1) were diastereoselectively synthesized by exploiting osmium-catalyzed asymmetric dihydroxylation based on the Sharpless procedure. The absolute configuration of the newly formed

Full text of DOI:10.3987/COM-97-7892

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