Synthesis of New Phospholipids Linked to Steroid-Hormone Derivatives Designed for Two-Dimensional Crystallization of Proteins

DOI: 10.1002/hlca.19910740810

Source and publish data:

Helvetica Chimica Acta p. 1697 - 1706 (1991)

Update date:2022-08-04

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Authors:

Lebeau, Luc

Oudet, Pierre

Mioskowski, Charles

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Article abstract of DOI:10.1002/hlca.19910740810

The synthesis of phospholipids 1_n-3_n, rationally designed for two-dimensional crystallization of progesterone and estradiol receptors, is reported.The structure of theses lipids provides them with essential properties such as fluidity and stability when spread into monolayers at the air/H2O interface, affinity for the protein to be crystallized, and accessibility of the ligand under the lipid monolayer.

Full text of DOI:10.1002/hlca.19910740810

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