Tetrahedron Letters p. 7171 - 7174 (1991)
Update date:2022-09-26
Topics:
Manoharan, Muthiah
Guinosso, Charles J.
Cook, P. Dan
The sugar ring of adenosine was alkylated at the 2′-O- position using N-(5-bromopentyl) phthalimide and the modified nucleoside was chemically incorporated into oligonucleotide diesters, thioates and RNA analogs. The free amino group, available after oligonucleotide deprotection, is useful for site-specific introduction of reporter groups and therapeutic agents at the 2′-position. This novel methodology permits multiple labeling of nucleic acids in the minor groove.
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