The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element

DOI: 10.1016/S0960-894X(99)00459-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2767 - 2772 (1999)

Update date:2022-08-03

Topics:

Authors:

Wiley, Michael R.

Weir, Leonard C.

Briggs, Steven L.

Chirgadze, Nickolay Y.

Clawson, David

Gifford-Moore, Donetta S.

Schacht, Aaron L.

Smith, Gerald F.

Vasudevan, Vasu

Zornes, Larry L.

Klimkowski, Valentine J.

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Article abstract of DOI:10.1016/S0960-894X(99)00459-X

Modeling of neutral or mildly basic functional groups in the S1 site of thrombin led to the targeting of imidazole as a S1 binding element and correctly predicted the optimal chain length for connecting this group with the S2 and S3 binding elements. Deri

Full text of DOI:10.1016/S0960-894X(99)00459-X

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Product name:2-Propenoic acid, 3-[1-[(4-methylphenyl)sulfonyl]-1H-imidazol-4-yl]-, methyl ester, (E)-

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