Bioorganic and Medicinal Chemistry Letters p. 2767 - 2772 (1999)
Update date:2022-08-03
Topics:
Wiley, Michael R.
Weir, Leonard C.
Briggs, Steven L.
Chirgadze, Nickolay Y.
Clawson, David
Gifford-Moore, Donetta S.
Schacht, Aaron L.
Smith, Gerald F.
Vasudevan, Vasu
Zornes, Larry L.
Klimkowski, Valentine J.
Modeling of neutral or mildly basic functional groups in the S1 site of thrombin led to the targeting of imidazole as a S1 binding element and correctly predicted the optimal chain length for connecting this group with the S2 and S3 binding elements. Deri
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