The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element

DOI: 10.1016/S0960-894X(99)00459-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2767 - 2772 (1999)

Update date:2022-08-03

Topics:

Authors:

Wiley, Michael R.

Weir, Leonard C.

Briggs, Steven L.

Chirgadze, Nickolay Y.

Clawson, David

Gifford-Moore, Donetta S.

Schacht, Aaron L.

Smith, Gerald F.

Vasudevan, Vasu

Zornes, Larry L.

Klimkowski, Valentine J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00459-X

Modeling of neutral or mildly basic functional groups in the S1 site of thrombin led to the targeting of imidazole as a S1 binding element and correctly predicted the optimal chain length for connecting this group with the S2 and S3 binding elements. Deri

Full text of DOI:10.1016/S0960-894X(99)00459-X

Products guided by the article

Product name:2-Propenoic acid, 3-[1-[(4-methylphenyl)sulfonyl]-1H-imidazol-4-yl]-, methyl ester, (E)-

Cas No:139284-99-4

R&D Labs maybe for 139284-99-4

Zhejiang Haizhou Pharmaceutical Co., Ltd.

website:https://www.haizhoupharma.com/

Contact:+86-576-88221016

Address:No. 19, Donghai 5th Avenue, Yanhai Industrial Zone, Linhai, Zhejiang, China
Nantong Chem-land Co., Ltd.

Contact:86 513 85512619

Address:Rm.1306, Building A, Wenfeng Mansion,168 Gongnong Road, Nantong Jiangsu China
Hisyntech Corporation Limited

Contact:0086-22-23410962

Address:17-201, Ningfuli, Shuishanggongyuandong road,Nankai district, Tianjin, China
LIANYUNGANG YC FINE CHEMICAL CO., LTD

Contact:+86-518-858 99188

Address:Shangdong Modern Bldg, South Greenpark Road, Lianyungang, Jiangsu Pro. China
ABA Chemicals (Shanghai) Limited

Contact:021- 5115 9199-232

Address:Suite 18D, #201 Ningxia Road,

Relevant to this article

One-pot synthesis of novel isoindoline-1,3-dione derivatives bearing 1,2,4-triazole moiety and their preliminary biological evaluation

Doi:10.1016/j.ejmech.2012.06.041
(2012)
Potassium channel blocking 1,2-bis(aryl)ethane-1,2-diamines active as antiarrhythmic agents

Doi:10.1016/j.bmcl.2019.03.006
(2019)
Bis-heterocycles. Part I: Tetrahydro-5,5′- bi(1,2,4-triazin-6-ones)

Doi:10.1515/znb-2018-0148
(2018)
Discovery of a novel chemotype of tyrosine kinase inhibitors by fragment-based docking and molecular dynamics

Doi:10.1021/ml3001984
(2012)
One-Pot Synthesis of 2,4-Diacyl Thiophenes from α-Oxo Ketene Dithioacetals and Propargylic Alcohols

Doi:10.1021/acs.joc.0c01093
(2020)
Cross-metathesis approach to produce precursors of nylon 12 and nylon 13 from microalgae

Doi:10.1039/c4ra10980e
(2014)

Article Doi