Erratum: Mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2) as an antiinflammatory target: Discovery and in vivo activity of selective pyrazolo[1,5-a]pyrimidine inhibitors using a focused library and structure-based optimization approach (Journal of Medicinal Chemistry (2012) 55 (6700-6715) DOI: 10.1021/jm300411k)

Full text of DOI:10.1021/jm3013954

Addition/Correction
pubs.acs.org/jmc
Correction to Mitogen-Activated Protein Kinase-Activated Protein
Kinase 2 (MAPKAP-K2) as an Antiinflammatory Target: Discovery and
in Vivo Activity of Selective Pyrazolo[1,5‑a]pyrimidine Inhibitors
Using a Focused Library and Structure-Based Optimization Approach
Tomomi Kosugi, Dale R. Mitchell,* Aiko Fujino, Minoru Imai, Mika Kambe, Shinji Kobayashi,
Hiroaki Makino, Yohei Matsueda, Yasuhiro Oue, Kanji Komatsu, Keiichiro Imaizumi, Yuri Sakai,
Satoshi Sugiura, Osami Takenouchi, Gen Unoki,* Yuko Yamakoshi, Vicky Cunliffe, Julie Frearson,
Richard Gordon, C. John Harris, Heidi Kalloo-Hosein, Joelle Le, Gita Patel, Donald J. Simpson,
Brad Sherborne, Peter S. Thomas, Naotaka Suzuki, Midori Takimoto-Kamimura, and Ken-ichiro Kataoka
Journal of Medicinal Chemistry 2012, 55, 6700−6715. DOI: 10.1021/jm300411k
S
* Supporting Information
Page 6713. An updated Supporting Information file associated
with this Addition and Correction is available with the following
modifications:
Page 6707. The entries 51, 52, and 53 in Table 5 were incorrectly
shown with R6 as H rather than methyl. The corrected Table 5 is
provided below.
Table 5. IC50 values for 7-Position Derivatives
Published: October 25, 2012
© 2012 American Chemical Society
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dx.doi.org/10.1021/jm3013954 | J. Med. Chem. 2012, 55, 10312−10313

Journal of Medicinal Chemistry
Addition/Correction
Page S23 of Supporting Information. Compound 46 is now
named correctly as the S enantiomer.
Page S31 of Supporting Information. Compound 45 is now
named correctly as the racemate.
ASSOCIATED CONTENT
* Supporting Information
■
S
Corrected file (see above) associated with this Addition and
Correction that lists experimental details for the synthesis of
all compounds and spectral data of all intermediates and final
compounds; kinase selectivity panel for (S)-44; THP-1 cell based
assay concentration effect curves for (S)-44, 59, and 64. This
material is available free of charge via the Internet at http://pubs.
acs.org.
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