Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia

DOI: 10.1016/j.bmcl.2012.07.007

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 5595 - 5599 (2012)

Update date:2022-07-29

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Authors:

Cutshall, Neil S.

Onrust, Rene

Rohde, Alex

Gragerov, Sasha

Hamilton, Lauren

Harbol, Kevin

Shen, Hui-Rong

McKee, Shawn

Zuta, Charles

Gragerova, Galina

Florio, Vince

Wheeler, Thomas N.

Gage, Jennifer L.

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Article abstract of DOI:10.1016/j.bmcl.2012.07.007

A series of 2-methoxyacylhydrazones were optimized to yield compounds with high affinity for PDE10A. Several compounds demonstrated efficacy in animal models of schizophrenia, including conditioned avoidance response and a pro-psychotic phencyclidine hyperactivity model.

Full text of DOI:10.1016/j.bmcl.2012.07.007

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