Total chiral synthesis of azole antifungals via α-hydroxylation of ketones

DOI: 10.1016/0040-4039(96)01887-4

Source and publish data:

Tetrahedron Letters p. 8117 - 8120 (1996)

Update date:2022-08-03

Topics:

Authors:

Gala, Dinesh

DiBenedetto, Donald J.

Mergelsberg, Ingrid

Kugelman, Max

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(96)01887-4

The use of camphorsulfonyl oxaziridines for the preparation of 2',4'-difluoro-(R)-2-hydroxypropiophenone, (2), a key intermediate for the synthesis of azole antifungals Sch 42427 and ER-30346 (1) in excellent enantiomeric excess and high chemical yield is described.

Full text of DOI:10.1016/0040-4039(96)01887-4

Products guided by the article

Product name:(-)-((8,8-Dichlorocamphoryl)sulfonyl)imine

Cas No:139628-15-2

R&D Labs maybe for 139628-15-2

Yicheng Goto Pharmaceuticals Co.,Ltd.

Contact:+86 710 3423122

Address:5th Floor,East Gate of Building #2,Servo-Industrial Park,1st Qilin Road,Xiangyang,Hubei,China
NanJing KaiHeng Chemical CO., LTD.

Contact:+86-25-85768391

Address:RM.1704, D, WANDA PLAZA, NO.110, MIDDLE JIANGDONG ROAD, NANJING, CHINA
Shanghai AoBo Bio-Pharmaceutical Technology Co., Ltd.

Contact:+86-21-51320130-801, 816

Address:Room 601, No. 1011, Halei Road, Zhangjiang High-Tech Park, Pudong, Shanghai
Jiangsu Hualun Chemical Industry Co., Ltd

website:http://www.hualunchem.com

Contact:+86-0514-86464168 86507985

Address:39# Middle Renmin Road, Dinghuo Town
Anhui Sunsing Chemicals Co.,Ltd

website:http://www.sunsingchem.com

Contact:0086-566-2023179

Address:Jin An industry park, Chizhou economic technical development zone, Anhui

Relevant to this article

Iron-catalyzed C-N bond formation via oxidative C_sp3-H bond functionalization adjacent to nitrogen in amides and anilines: Synthesis of N-alkyl and N-benzyl azoles

Doi:10.1016/j.tetlet.2015.05.048
(2015)
A Novel Approach to Bicyclic Alkaloids Using a Tandem Diastereoselective Acyliminocyclization and Retro Diels-Alder Reaction Sequence. Synthesis of (+)-Indolizidine and (+)-Laburnine

Doi:10.1246/cl.1991.2135
(1991)
Hydrogen atom abstraction reactions in organic synthesis. A formal total synthesis of racemic podophyllotoxin

Doi:10.1021/jo00036a030
(1992)
Iron-catalyzed cross-coupling of N-heterocyclic chlorides and bromides with arylmagnesium reagents

Doi:10.1021/ol302136c
(2012)
Stereo- and Regio-controlled Carbon-Carbon Bond Formation Mediated by Tungsten in the s-trans-η⁴-Diene Cationic Intermediates

Doi:10.1039/c39920000045
(1992)
Hypohalous acid-mediated halogenation of resveratrol and its role in antioxidant and antimicrobial activities

Doi:10.1016/j.foodchem.2012.05.043
(2012)

Article Doi