Total chiral synthesis of azole antifungals via α-hydroxylation of ketones

DOI: 10.1016/0040-4039(96)01887-4

Source and publish data:

Tetrahedron Letters p. 8117 - 8120 (1996)

Update date:2022-08-03

Topics:

Authors:

Gala, Dinesh

DiBenedetto, Donald J.

Mergelsberg, Ingrid

Kugelman, Max

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Article abstract of DOI:10.1016/0040-4039(96)01887-4

The use of camphorsulfonyl oxaziridines for the preparation of 2',4'-difluoro-(R)-2-hydroxypropiophenone, (2), a key intermediate for the synthesis of azole antifungals Sch 42427 and ER-30346 (1) in excellent enantiomeric excess and high chemical yield is described.

Full text of DOI:10.1016/0040-4039(96)01887-4

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