Total chiral synthesis of azole antifungals via α-hydroxylation of ketones

DOI: 10.1016/0040-4039(96)01887-4

Source and publish data:

Tetrahedron Letters p. 8117 - 8120 (1996)

Update date:2022-08-03

Topics:

Authors:

Gala, Dinesh

DiBenedetto, Donald J.

Mergelsberg, Ingrid

Kugelman, Max

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4039(96)01887-4

The use of camphorsulfonyl oxaziridines for the preparation of 2',4'-difluoro-(R)-2-hydroxypropiophenone, (2), a key intermediate for the synthesis of azole antifungals Sch 42427 and ER-30346 (1) in excellent enantiomeric excess and high chemical yield is described.

Full text of DOI:10.1016/0040-4039(96)01887-4

Products guided by the article

Product name:(-)-((8,8-Dichlorocamphoryl)sulfonyl)imine

Cas No:139628-15-2

R&D Labs maybe for 139628-15-2

Dezhou Longteng Chemical Co., Ltd.

website:http://www.sodium-methoxide.cn/

Contact:0086-18866052283

Address:Xinhua Industrial Zone, Dezhou City, Shandong Province, China
Taizhou Shengxing Chempharm Co.,Ltd

Contact:+86-576-88516600

Address:Yantou Chemical Zone Jiaojiang Taizhou Zhejiang China
Wuhan Fortuna Chemical Co.,Ltd

website:http://www.fortunachem.com

Contact:86-27-59207850

Address:Add: Room 2015, No.2 Building, Kaixin Mansion No.107 Jinqiao Avenue, Wuhan, China
Sdow

website:http://www.sdowchem.com

Contact:86-135-2193 7483

Address:8-106 taiyue building
Beijing Stable Chemcial Co.ltd

Contact:86-10-63785052

Address:A1301 Technological Edifice. No.4 FuFeng Road,FengTai District, Beijing. China

Relevant to this article

Iron-catalyzed C-N bond formation via oxidative C_sp3-H bond functionalization adjacent to nitrogen in amides and anilines: Synthesis of N-alkyl and N-benzyl azoles

Doi:10.1016/j.tetlet.2015.05.048
(2015)
A Novel Approach to Bicyclic Alkaloids Using a Tandem Diastereoselective Acyliminocyclization and Retro Diels-Alder Reaction Sequence. Synthesis of (+)-Indolizidine and (+)-Laburnine

Doi:10.1246/cl.1991.2135
(1991)
Hydrogen atom abstraction reactions in organic synthesis. A formal total synthesis of racemic podophyllotoxin

Doi:10.1021/jo00036a030
(1992)
Iron-catalyzed cross-coupling of N-heterocyclic chlorides and bromides with arylmagnesium reagents

Doi:10.1021/ol302136c
(2012)
Stereo- and Regio-controlled Carbon-Carbon Bond Formation Mediated by Tungsten in the s-trans-η⁴-Diene Cationic Intermediates

Doi:10.1039/c39920000045
(1992)
Hypohalous acid-mediated halogenation of resveratrol and its role in antioxidant and antimicrobial activities

Doi:10.1016/j.foodchem.2012.05.043
(2012)

Article Doi