Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue.

DOI: 10.1021/jm00086a016

Source and publish data:

Journal of medicinal chemistry p. 1466 - 1471 (1992)

Update date:2022-09-26

Topics: Synthesis Characterization Enantiomers Stereoisomers Probes Allyl

Authors:

Neumeyer

Kula Kula

Baldessarini

Baindur Baindur

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00086a016

Substituted 1-phenyl-3-benzazepines (e.g., SKF 38393 and fenoldopam) exhibit stereoselectivity in moderately high-affinity binding to and partial agonist activation of D1 dopamine receptors. The 3-allyl (APB) and the 3-allyl-6-chloro (6-Cl-APB) analogues

Full text of DOI:10.1021/jm00086a016

Products guided by the article

Product name:1H-3-Benzazepine, 6-bromo-2,3,4,5-tetrahydro-7,8-dimethoxy-1-phenyl-, (S)-

Cas No:139689-13-7

R&D Labs maybe for 139689-13-7

Suzhou Chiral Pharmaceuticals Co., Ltd.

Contact:86-0512-63197058

Address:Building A, No. 2358, Chang'an Road, Wujiang Science Park
Chengdu Baishixing Science and Technology Industry Co., Ltd.

website:http://www.cd-bsx.com

Contact:+86-28-88531548

Address:#217,North of Industry Road,Heshan Town,Pujiang County,Chengdu,Sichuan,China.
Jinan Hongfangde Pharmatech Co.LTD

Contact:0531-88870908

Address:F Bldg,750#,Shunhua Rd,New&High-tech Zone,Jinan,Shandong,China 250101
Jiangsu Allyrise Pharmaceutical Co., Ltd.(expird)

Contact:+86-523-86818997

Address:Taizhou,Jiangsu Province,CHINA
Zibo Ocean International Trade Co.,Ltd(expird)

Contact:+86 533 5160706

Address:1117, Hongtai Bld., Songling rd, Zichuan,Zibo,Shandong,China

Relevant to this article

TANDEM ALKYNE INSERTION AND ALLYL SULFONIUM YLIDE REARRANGEMENT OF γ,δ-ALKYNYL-α'-DIAZOKETONES

Doi:10.1016/0040-4039(92)88041-3
(1992)
Reactions of β-(lithiomethyl)azines with nitriles as a route to pyrrolo-pyridines, - quinolines, -pyrazines, - quinoxalines and -pyrimidines

Doi:10.1016/S0040-4020(01)88196-5
(1992)
Synthesis and application of silica phenyl sulfonic acid as a solid acid heterogeneous catalyst for one-pot synthesis of 2-aryl-1-arylmethyl-1H-1,3- benzimidazoles and bis(indolyl)methanes in water

Doi:10.1002/jhet.765
(2011)
Photoluminescence color tuning of phosphorescent bis-cyclometalated iridium(III) complexes by ancillary ligand replacement

Doi:10.1016/j.dyepig.2012.05.026
(2012)
Novel oxazolo[4,5-g]quinazolin-2(1H)-ones: Dual inhibitors of EGFR and Src protein tyrosine kinases

Doi:10.1016/j.ejmech.2012.06.055
(2012)
CD Spectral Diagnosis of Absolute Configuration of Tetrahedral or Pseudo-Tetrahedral Metal Complexes of Salicylideneiminates

Doi:10.1246/bcsj.65.606
(1992)

Article Doi