Stereoisomeric probes for the D1 dopamine receptor: synthesis and characterization of R-(+) and S-(-) enantiomers of 3-allyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue.

DOI: 10.1021/jm00086a016

Source and publish data:

Journal of medicinal chemistry p. 1466 - 1471 (1992)

Update date:2022-09-26

Topics: Synthesis Characterization Enantiomers Stereoisomers Probes Allyl

Authors:

Neumeyer

Kula Kula

Baldessarini

Baindur Baindur

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Article abstract of DOI:10.1021/jm00086a016

Substituted 1-phenyl-3-benzazepines (e.g., SKF 38393 and fenoldopam) exhibit stereoselectivity in moderately high-affinity binding to and partial agonist activation of D1 dopamine receptors. The 3-allyl (APB) and the 3-allyl-6-chloro (6-Cl-APB) analogues

Full text of DOI:10.1021/jm00086a016

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