An Improved Synthesis of 1,2,9,9a-Tetrahydrocyclopropabenzindol-4-one (CBI): A Simplified Analogue of the CC-1065 Alkylation Subunit

DOI: 10.1021/jo00036a023

Source and publish data:

Journal of Organic Chemistry p. 2873 - 2876 (1992)

Update date:2022-08-02

Topics:

Authors:

Boger, Dale L.

Yun, Weiya

Teegarden, Bradley R.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00036a023

A concise and improved synthesis of 11, the immediate precursor to N-BOC-CBI and related analogues of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropabenzindol-4-one alkylation subunit, is detailed based on a direct 5-exo-trig aryl radical-al

Full text of DOI:10.1021/jo00036a023

Products guided by the article

Product name:2-amino>-4-(benzyloxy)-1-bromonaphthalene

Cas No:139975-99-8

R&D Labs maybe for 139975-99-8

Wuhan HengHeDa Pharm Co., Ltd

Contact:86-27-84888681

Address:Wuhan economic & technology development zone
APOLLO HEALTHCARE RESOURCES

Contact:+65 9658 0999

Address:26 Sin Ming Lane, Midview City, #05-118, Singapore 573971
Suzhou JMS Chemical Co., Ltd.

Contact:+86-15995924277

Address:WuZhongOu suzhou new south road 89
KINHENG CHEMICAL(SHANGHAI)CO., LTD.

Contact:+8621-60490170

Address:Room401, No.28,Lane 189, Yangshupu Rd. Shanghai, China.
Wuhan Fortuna Chemical Co.,Ltd

website:http://www.fortunachem.com

Contact:86-27-59207850

Address:Add: Room 2015, No.2 Building, Kaixin Mansion No.107 Jinqiao Avenue, Wuhan, China

Relevant to this article

Non-symmetrical bis(aminoalkyl)phosphinates: New ligands with enhanced binding of Cu(ii) ions

Doi:10.1039/c8nj01094c
(2018)
Chemistry of alpha-aminonitriles. Aziridine-2-carbonitrile: photochemical formation from 2-aminopropenenitrile

Doi:10.1002/hlca.19900730524
(1990)
Fixed-charge labels for simplified reaction analysis: 5-hydroxy-1,2,3- triazoles as byproducts of a copper(I)-catalyzed click reaction

Doi:10.1016/j.tetlet.2011.03.094
(2011)
A general palladium-catalyzed carbonylative synthesis of chromenones from salicylic aldehydes and benzyl chlorides

Doi:10.1002/chem.201301774
(2013)
Boronic Acid Catalyzed Hydrolyses of Salicylaldehyde Imines

Doi:10.1021/jo00004a031
(1991)
Direct conjugate alkylation of α,β-unsaturated carbonyls by Ti^III-catalysed reductive umpolung of simple activated alkenes

Doi:10.1039/c5ob02631h
(2016)

Article Doi