An Improved Synthesis of 1,2,9,9a-Tetrahydrocyclopropabenzindol-4-one (CBI): A Simplified Analogue of the CC-1065 Alkylation Subunit

DOI: 10.1021/jo00036a023

Source and publish data:

Journal of Organic Chemistry p. 2873 - 2876 (1992)

Update date:2022-08-02

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Authors:

Boger, Dale L.

Yun, Weiya

Teegarden, Bradley R.

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Article abstract of DOI:10.1021/jo00036a023

A concise and improved synthesis of 11, the immediate precursor to N-BOC-CBI and related analogues of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropabenzindol-4-one alkylation subunit, is detailed based on a direct 5-exo-trig aryl radical-al

Full text of DOI:10.1021/jo00036a023

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