Discovery of 1-(β-amino substituted-β-alanyl)-N,N- dimethylindoline-2-carboxamides as novel nonpeptide antagonists of nociceptin/orphanin FQ receptor: Efficient design, synthesis, and structure-activity relationship studies

DOI: 10.1016/j.ejmech.2012.07.021

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European Journal of Medicinal Chemistry p. 228 - 242 (2012)

Update date:2022-07-29

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Authors:

Hayashi, Shigeo

Ohashi, Katsuyo

Nakata, Eriko

Emoto, Chie

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Article abstract of DOI:10.1016/j.ejmech.2012.07.021

Since the discovery of endogenous nociceptin/orphanin FQ (N/OFQ) peptide and N/OFQ peptide (NOP) receptor [or opioid-receptor-like-1 (ORL1) receptor], the structures, distribution, and pharmacology have been reported in detail. N/OFQ and NOP receptor are

Full text of DOI:10.1016/j.ejmech.2012.07.021

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