Synthesis of 3-aminopyrrolidin-2-ones by an intramolecular reaction of aziridinecarboxamides

Article abstract of DOI:10.1016/0040-4020(96)00523-6

The synthesis of 4,5 disubstituted-3 amino-γ-lactams from N- substituted aziridinecarboxamides is described. Bicyclic aziridine derivatives were obtained from 1-N-Boc-aziridinecarboxamides under kinetically controlled conditions. Oxiranecarboxamides showed similiar behavior and gave 3-hydroxy-lactams.