Chemistry - A European Journal p. 3932 - 3938 (2014)
Update date:2022-08-04
Topics:
Hu, Jiantao
Xu, Huacheng
Nie, Pengju
Xie, Xiaobo
Nie, Zongxiu
Rao, Yu
A transition-metal-free oxidative C-N coupling method has been developed for the synthesis of 1H-azaindazoles and 1H-indazoles from easily accessible hydrazones. The procedure uses TEMPO, a basic additive, and dioxygen gas as the terminal oxidant. This reaction demonstrates better reactivity, functional group tolerance, and broader scope than comparable metal catalyzed reactions. A transition-metal-free oxidative C-N coupling method has been developed for the synthesis of 1H-azaindazoles and 1H-indazoles from easily accessible hydrazones (see scheme). The procedure uses TEMPO, a basic additive, and dioxygen gas as the terminal oxidant. This reaction demonstrates better reactivity, functional group tolerance, and broader scope than comparable metal catalyzed reactions. TEMPO=2,2,6,6-tetramethyl-1-piperidinyloxy.
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Doi:10.1055/s-1990-26982
(1990)Doi:10.1002/adsc.201901525
(2020)Doi:10.1021/jo00001a089
(1991)Doi:10.1246/cl.1990.905
(1990)Doi:10.1039/c39900000739
(1990)Doi:10.1002/hlca.19900730417
(1990)